参附注射液对老年患者腹部手术后早期康复的影响

Effect of Shenfu Injection on Early Rehabilitation of the Senile Patients after Abdominal Surgery

目的:观察参附注射液对普通外科老年患者手术后早期康复的影响。方法:100例老年腹部手术患者随机分为对照组50例和参附注射液组(SF组)50例。SF组于手术后第一天开始在常规治疗基础上,每天加用50ml参附注射液静脉滴注,连用5天,对照组仅行常规治疗。术后每天观察并记录肠蠕动恢复时间、肛门排气时间、切口愈合情况,血常规、凝血功能、肝功能、组织修复相关因子(SOD、MDA、TNF-α)及免疫功能指标(IgG、IgA、IgM)的变化。结果:SF组患者平均肠蠕动恢复时间及平均肛门排气时间较对照组显著缩短(P<0.05)。手术前后SF组与对照组比较血常规、凝血功能及肝功能指标无显著差异。术后所有病例SOD显著降低,SF组降幅小于对照组(P<0.05)。对照组术后MDA明显升高(P<0.05)。对照组术后TNF-α明显升高(P<0.05)。术后SF组IgG、IgA较对照组升高。结论:参附注射液能降低手术后应激反应。减少炎症因子的表达,减轻组织损伤,促进血液循环,有助于老年患者腹部手术后胃肠功能恢复。

Objective：To explore the effect of shenfu injection on early rehablilitation of the senile patients after surgery.Methods：100 cases were randomly divided into the contrast group（C group with 50cases） and the shenfu group（SF group with 50 cases）.The SF group was treated by mainline with 50ml shenfu injection 5 days before and after surgery, and the day taking surgery.The C group was treated by normally. The clinical symptoms were observed each day and the time of intestines creepage,anus exhaust,and incision concrescence was recorded. The level of C reactive protein,hydrocortisone concentration,some cell genes,SOD and MDA were also measured.Results：The fatigue score after operation,the level of C reactive protein,hydrocortisone concentration,TNF-α and MDA in the SF group were obviously decreased than those in the C group（P〈0.01orP〈0.05）.The level of IL-2 and SOD in the SF group was significantly improved than that in the C group（P〈0.01）. Conclusion：Shenfu injection can decrease the response to a stimulus,the express of inflammatory factor, the systematical trauma after operation. It can improve the early rehabilitation of the senile patients after general surgery.