无淋巴结转移的直肠癌nm23-H1、p21表达与预后的关系

The relation between expression of nm23-H1 and p21 in rectal adenocarcinomas withoutIymph node metastasis and the clinical prognosis

目的探讨无淋巴结转移的直肠癌中nm23－H1、p21表达与预后的关系。方法应用免疫组织化学方法观察84例无淋巴结转移的直肠腺癌nm23－H1、p21的表达。结果在生存期＜5年的32例患者中，nm23－H1阴性表达着26例（81．3％），p21阳性表达者28例（87．5％），在生存期＞5年的52例患者中，nm23－H1阴性表达者11例（21．2％），p21阳性表达着20例（38．5％），nm23－H1及p21在2组中表达差异有显著性（P＜0．05）。结论无淋巴结转移的直肠癌中nm23－H1低表达及p2I阳性表达与5年生存率密切相关，这对术后综合治疗方案选择有指导作用。

Objectivc To study the expression of nm23-H1 and p21 gene in rectaladenocarcinomas without lymph node metastasis and its relation to the clinical prognosis. Method 84cases were subjected to immunhistochemica1 study to observe the expresion of nm23-Hl and p2l protein inadenocarcinomas. Result Among 32 cases with less than 5 years survival, the negative expression ofnm23-H1 in adnocarcinomas was revealed in 26 cases (81. 3%), the positive expression of p21 inadenocorcinoma was revealed in 28 cases (87. 5%). However, among 52 cases with more than 5 yearssurvial, the negative expression of nm23-H1 was ll cases (21.2% ), the positive expresstion of p21 was20 cases (38. 5% ). The difference between two group was prominent (P<O. O5). Conclusion Thereare close relationship between the negative expression of nm23-H1 and positive expression of p21 in rectaladenocarcinomas without lymph node metastasis and 5-year survival rate.