血清α-L一岩藻糖苷酶在诊断原发性肝癌中的临床应用

Clinical study of serumα-L-fucosidase for the diagnosis of primary hepatic carcinoma

目的研究血清α－L一岩藻糖着酶（AFU）对原发性肝癌的诊断意义。方法分别测定76例原发性肝癌、57例肝硬化、112例非肝脏恶性肿瘤及80例正常对照者的血清AFU；对76例原发性肝癌还同时测定血清甲脂蛋白（AFP）；对18例手术后患者随访测定AFU。结果原发性肝癌血清AFU活性显著高于其它各组。血清AFU和AFP对原发性肝癌的诊断敏感性分别为80．3％和76．3％，联合检测AFU和AFP的诊断敏感性提高到92．1％。原发性肝癌手术切除癌肿后血清AFU活性明显下降，复发时可再度升高。结论血清AFU对原发性肝癌的诊断和复发监测有重要价值。

Objective To study the significance of serum a-L-fucosidase (AFU) in the diagnosis ofprimary hepatic carcinoma (PHC). Method The activities of serum AFU were measured in 76 cases ofPHC, 57 cases of liver cirrhosis, ll2 cases of other malignant neoplasms and 8o healthy subjects. Besidesserum AFU, in 76 patients with PHC, the serum AFP was measured at the same time. In 18 patients withPHC, follow-up detections of serum AFU were carried out after tumors resection. ResuIt The AFUactivities in patients with PHC were significantly higher than any other groups. The diagnostic sensitivitiesof serum AFU and AFP in patients with PHC were 8O. 3% and 76. 3% respectivecy, and the combineddiagnostic sensitivity of AFU and AFP reached the 1evel of 92.1%. The serum AFU in patients with PHCwas found to be significantly reduced after operations. In patients with PHC recurrence, the serum AFUwas found to be significantly increased again. Conclusion The serum AFU was a useful marker for thediagnosis of PHC and the monitoring of PHC recurrence.