摘要
采用炭末法和记录小鼠用药后的泻下次数,研究大黄中结合蒽醌对小鼠的促进肠蠕动和致泻作用,探讨其治疗参考剂量和量-效、时-效关系,并测定主要药动学参数。结果表明,结合蒽醌有明显的促进肠蠕动和致泻作用,促进肠蠕动半效剂量为18.22～25.79mg/kg,致泻作用的治疗参考剂量为150.48～224.45mg/kg,在一定剂量范围内量—效、时—效呈直线性相关,体内半衰期为5.10h。
The effects of Rhubarb combined anthraquinone on promoting intestinal peristalsis,dose response relationship and pharmacokinetics were investigated in mice.The time of defecation and the appearance of stool were recorded by using the charcoal powder method.The results indicated that oral administration of combined anthraquinone significantly promoted the peristalsis and reduced diarrhea in mice.The reference dose of promoting peristalsis was 18 22～25 79mg/kg, and the dose of reducing diarrhea was 150 48mg/kg.Both results of dose response and time response were linear relationship.The t 1/2 was 5 10 hours.
出处
《中国实验方剂学杂志》
CAS
1999年第6期53-55,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
大黄
结合蒽醌
药物动力学
Rhubarb
combined anthraquinone
pharmacokinetics
