变应原疫苗对变态反应性鼻炎患者血清中Th细胞漂移的临床研究

Th cell drift induced by allergen vaccine in patients with allergic rhinitis

目的:观察变应原疫苗(商品名阿罗格,简称NHD)对变态反应性鼻炎患者血清中Th1、Th2细胞水平的影响。方法:3年期间收集30位变应性鼻炎患者,15例(A组)根据变应原进行特异性免疫治疗,15例(B组)仅鼻用糖皮质激素,观察治疗前后的临床疗效及免疫学标志白细胞介素-2(IL-2)、白细胞介素-13(IL-13)的变化情况。结果:A组(特异性免疫治疗组)有效率91.83%,B组(鼻用糖皮质激素组)有效率89.67%。A组变应性鼻炎患者在经NHD治疗后血清Th1细胞因子IL-2含量显著增高,而Th2细胞因子IL-13含量显著减少,治疗前后比较差异有统计学意义(P<0.05)。B组IL-2、IL-13含量治疗前后差异无统计学意义(P>0.05)。结论:特异性免疫治疗是治疗变应性鼻炎的有效方法。用NHD特异性免疫治疗能通过对变应性鼻炎患者血中Th1/Th2细胞产生的细胞因子IL-2、IL-13比例的平衡,来纠正Th1/Th2细胞失平衡,能明显改善患者的临床症状,Th1/Th2平衡假说得到初步证实。

Objective： To observe the influence of the serum level of Th1 and Th2 in patients with allergic rhinitis accepted allergen vaccine（NHD） therapy.Methods： Fifteen patients with allergic rhinitis for three years（group A） were underwent special immunotherapy and another fifteen patients（group B） were treated with medication only intranasal corticosteroids.Clinical efficacy and the level of immunity index IL-2,IL-13 in venous blood was observed.Results： The total effective rate of allergic rhinitis was 91.83% in group A,and 89.67% in group B,there was significant difference between them（P〈0.05）.The level of serum IL-2 increased and IL-13 decreased in group A after treatment（P〈0.01）.In group B,the level of serum IL-2 and IL-13 was not significant different between pre-and post-treatment（P〉0.05）.Conclusion： Th1,Th2 balance hypothesis has been initially confirmed,so special immunotherapy is a sort of effective method for treating perennial allergic rhinitis.