摘要
能量代谢障碍是心跳呼吸骤停后脑损伤的主要病理生理改变,其损伤机制与心跳骤停后全脑缺血/再灌注导致的脑组织氧供和能量代谢紊乱有关。线粒体是产生三磷酸腺苷的主要场所,也是缺血/再灌注损伤的重要靶器官,它的损伤可能是导致脑细胞能量代谢障碍的关键。现就全脑缺血/再灌注后线粒体损伤变化的研究进展予以综述。
Energy metabolism failure is a main pathophysiological change of brain injury after cardiac arrest.Its damage mechanism is associated with brain tissue oxygen supply and energy metabolism disorder caused by complete cerebral ischemia-reperfusion after cardiac arrest.Mitochondria is the main site to produce adenosine triphosphate,as well as the targeted organ in ischemia-reperfusion,so its injury may be the key of causing cellular energy metabolism disturbance.The research progress of mitochondrial changes after global cerebral ischemia-reperfusion are reviewed here.
出处
《医学综述》
2011年第11期1619-1621,共3页
Medical Recapitulate
关键词
脑
缺血/再灌注
线粒体
Brain
Ischemia-reperfusion
Mitochondria
