超微病理在肾脏疾病诊断中的作用

The Function of Ultrastructural Diagnosis in Kidney Disease

超微病理诊断指从细胞器水平观察分析病变组织细胞的改变,对疾病的诊断及鉴别诊断发挥着不可替代的作用。通过观察肾小球超微结构变化(如肾小球毛细血管内皮细胞、基底膜的结构和厚度、上皮细胞及其足突变化等)以及对肾小球超微结构与功能相结合的研究,发现超微病理诊断对肾脏疾病起到决定性诊断作用、重要参考作用及部分修正作用,是光镜、免疫荧光检查的互补或印证。

Ultrastructural diagnosis refers to observation and analysis on lesions of cellular changes on organelle level,which plays an irreplaceable role in disease diagnosis and identification.Through the observation of glomerular ultrastructural changes（glomerular capillary endothelial cells,basement membrane structure and thickness,epithelial cells and its podocyte changes）and glomerular ultrastructure and function combination research,it is found that ultrastructural diagnosis plays a decisive role and important referential and partly corrective function in renal disease diagonsis,which is a complementary or confirmation of light microscope and immunofluorescence diagnosis.