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Ghrelin与透析患者的关系研究进展 被引量：2

Research Progress of the Relationship between Ghrelin and Dialysis Patients
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摘要 Ghrelin是一种生长激素促分泌素受体的内源性配体,主要来源于胃肠道,不仅能促进生长激素的分泌,还参与调节能量代谢。新近研究发现,Ghrelin与透析患者的关系密切,高Ghrelin水平与肾脏对其清除和降解减少有关。Ghrelin可能参与透析患者食欲、营养、炎症状况方面的调节。Ghrelin的两种不同分子形式对透析患者食欲状况的影响也备受关注。 Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor,mostly coming from gastrointestinal tract,which has the effect of not only stimulating the releasing of growth hormone,but also regulating energy metabolism.Recent studies found that ghrelin has a close relationship with dialysis patients,high ghrelin level is somehow related to the decreased clearance and degradation in the kidney.Ghrelin may be involved in the regulation of appetite,nutrition and inflammation status in dialysis patients.The influence of two molecular forms of ghrelin on appetite status in dialysis patients is attracting more attention from researchers.
作者 葛月辉 刘岩
机构地区 暨南大学第四附属医院肾内科
出处 《医学综述》 2011年第11期1660-1662,共3页 Medical Recapitulate
关键词 GHRELIN 透析 食欲 营养 炎症 Ghrelin Dialysis Appetite Nutrition Inflammation
分类号 R692 [医药卫生—泌尿科学] R334 [医药卫生—人体生理学]
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参考文献20

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  • 2Yoshimoto A,Mori K,Sugawara A,et al.Plasma ghrelin and desacyl ghrelin concentrations in renal failure[J].J Am Soc Nephrol,2002,13(11):2748-2752.
  • 3Asakawa A,Inui A,Fujimiya M,et al.Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin[J].Gut,2005,54(1):18-24.
  • 4Pérez-Fontán M,Cordido F,Rodríguez-Carmona A,et al.Plasma ghrelin levels in patients undergoing haemodialysis and peritoneal dialysis[J].Nephrol Dial Transplant,2004,19(8):2095-2100.
  • 5Firczyk P,Ignacy W,Adamczak M,et al.Postprandial secretion of ghrelin in hemodialysis patients with and without diabetic nephropathy[J].Pol Arch Med Wewn,2009,119(7/8):447-452.
  • 6张昭馥,臧贵明,付芳婷,赵丽,赵云涛,张肇康.血液透析对血浆Ghrelin的影响[J].第三军医大学学报,2002,24(9):1084-1085. 被引量：5
  • 7何莲,张爱华,阿拉塔,韩庆烽,朱宁,范敏华.腹膜透析和血液透析患者血浆Ghrelin水平的研究(英文)[J].中国现代医学杂志,2007,17(10):1153-1156. 被引量：2
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二级参考文献1

共引文献5

同被引文献33

  • 1陈亮,汪建,陈勇挺,熊敏,邓恒山.阻塞性睡眠呼吸暂停低通气综合征患者手术治疗前后血浆ghrelin水平变化的研究[J].中华临床医师杂志（电子版）,2011,5(20):6126-6127. 被引量：2
  • 2何莲,张爱华,阿拉塔,韩庆烽,朱宁,范敏华.腹膜透析和血液透析患者血浆Ghrelin水平的研究(英文)[J].中国现代医学杂志,2007,17(10):1153-1156. 被引量：2
  • 3Seim I, Collet C, Herington AC, et al. Revised genomie structure of the human ghrelin gene and identification of novel exons, alter- native splice variants and natural antisense transcripts. BMC Ge- nomics,2007,8 (2007) :298.
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  • 5Mori K , Yoshimoto A, Takaya K, et al. Kidney produces a novel acylated peptide, ghrelin. FEBS Letters, 2000,486 ( 3 ) : 213 - 216.
  • 6Yoshimoto K, Moil K, Sugawara A, et al. Plasma Ghrelin and Desacyl Ghrelin Concentrations in Renal Failure. J Am Soc Nephrol,2002,13 ( 11 ) :2748 - 2752.
  • 7Nagaya N, Kojima M. Hemodynamic and hormonal effects of hu- man ghrelin in healthy volunteers. Am J Physiol Regul Integr Comp Physio1,2001,280(5 ) : R1483 - R1487.
  • 8Asakawa A, Inui A, Fujimiya M, et al. Stomach regulates energy balance ghrelin and desacyl ghrelin. Gut,2005,54 (1) :18 -24.
  • 9Kojima M, Kangawa K, Ghrelin : structure and function . Physiol Rev, 2005,85 (2) :495 - 522.
  • 10Rodriguez Ayala E, Pecoits - Filho R. Associations between plas- ma ghrelin levels and body composition in end - stage renal dis- ease:a longitudinal study. Nephrol Dial Transplant, 2004, 19 (2) :421 -426.

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医学综述
2011年 第11期

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