培哚普利对高血压患者颈总动脉内膜中层厚度影响的临床研究

Effect of Perindopril on Common Carotid Arteries′ Intima-media Thickness in Essential Hypertensive Patients

目的探讨降血压和降血脂联合治疗对血脂正常或轻度升高的高血压患者颈总动脉结构的影响。方法 75例原发性高血压患者被随机分成两组:培哚普利组35例,珍菊降压片组40例,所有受试者同时服用辛伐他汀。在治疗前和治疗后18个月,分别用多普勒超声测定受试者左右两侧颈总动脉的内膜中层厚度(IMT)。结果与治疗前相比,两组患者的血压、总胆固醇和低密度脂蛋白胆固醇水平明显下降(P<0.01);IMT在两组患者中都有下降,而且在培多普利组更明显(P<0.05)。结论培哚普利可以逆转高血压患者颈总动脉结构的损害。

Objective To probe the effect of combinated antihypertension and cholesterol（CH） lowering treatment on the common carotid arteries intima-media thickness（IMT） in essential hypertensives（EH）with normal or slightly higher cholesterol（CH） levels.Methods 75 EH were divided into 2 groups： perindopril group 35 and zhen-ju group 40,All the subjects were treated with simvastatin 10mmg/day meanwhile they received the blood pressure-lowering treatment with perindorpril or Zhen-ju.The bilateral common carotid arteries′ IMT were determined by pulsed Dopler before and after 18 months treatment.Results After the treatment,we can see a marked decreace in BP,in CH and in the low density lipoprotein cholesterol（LDL-C）（P0.05） in all the 2 groups patients,and we can also see an obvious decreace in IMT in those patients of perindorpril group（P0.01）.Conclusion Perindopril may reserve or inhibit the structure′s damage of common carotid arteries′ in EH.