FHIT基因、细胞凋亡在宫颈鳞癌中的表达及意义

The Expression and Significance of FHIT Gene and Cell Apoptosis in Cervical Carcinoma

目的:探讨FHIT蛋白在宫颈癌中的表达及与细胞凋亡的关系。方法:采用免疫组化和Tunel标记法对62例Ⅰ～Ⅲ期宫颈鳞癌进行FHIT蛋白表达水平与细胞凋亡的检测。结果:(1)FHIT与病理分级、淋巴结转移有关,与年龄、临床分期及肿瘤大小无明显相关性(P>0.05)。(2)细胞凋亡与临床分期、病理分级、淋巴结转移及肿瘤大小均有一定的相关性(P<0.05)。(3)FHIT蛋白的表达与细胞凋亡有相关性。结论:FHIT基因和细胞凋亡在宫颈癌的发生、发展中起着重要作用,与宫颈癌的预后有关,FHIT基因与细胞凋亡有一定的相关性。

Objective：To discuss the expression and significance of FHIT protein and cell apoptosis in cervical carcinoma.Methods：Expression of FHIT protein was detected by immunohistochemical and the apoptosis positivity was detected by T-dUTP nick end labeling techniques（TUNEL）in 62 cases of squamous cell cervical carcinoma.Results：There were significant differences between FHIT expression and histological grades and lymphnode metastasis（P0.05）,FHIT expression was not correlated with age,clinical stage and diameter of the tumour.There were significant differences between cell apoptosis and histological grades,lymph node metastasis,clinical stage and diameter of the tumour.Cell apoptosis is related with.Conclusion：FHIT expression and cell apoptosis are associated with pathogenesis and development of cervical carcinoma,FHIT protein is associated with cell apoptosis.