肾癌组织中CapG蛋白的表达变化及临床意义

Expression and clinical significance of CapG protein in renal cell carcinoma

目的观察肾透明细胞癌(肾癌)组织中CapG蛋白的表达变化,并探讨其意义。方法选取132例肾癌标本(观察组)及40例癌旁正常肾组织标本(对照组),采用免疫组化SP法检测CapG蛋白的表达。结果对照组CapG蛋白阳性表达率为7.5%,明显低于观察组的56.1%,P<0.001。观察组CapG蛋白表达与淋巴结转移和预后有关(P均<0.05),与患者年龄、性别、T分期、病理分级、复发转移无显著相关(P均>0.05)。结论肾癌组织中CapG蛋白表达上调。其与肾癌的转移和预后有关。

Objective To detect the expression and the significance of CapG protein in renal cell carcinoma（RCC）.Methods The expression of CapG protein in 132 specimens of clear cell RCC（observe group） and 40 specimens of matched normal renal tissues（control group）was detected by immunohistochemistry,the correlations with clinicopathologic features and prognosis of the patients were analyzed.Results The positive rate of CapG protein was significantly higher in observe group than in control group（P0.001）.CapG expression was related to nodal disease（P0.05）,but not to gender,age,pT stage,tumor grade and distant metastasis or recurrence（P0.05）.The 5-year survival rate was significantly higher in CapG-negative patients than in CapG-positive patients（P0.005）.Conclusions CapG is highly expressed in cRCC and could contribute to tumor development and progression.