阿魏胶囊长期毒性试验对大鼠血液学的影响

Observation of hematologic indexes of rat with A-Wei Capsule in chronic toxic test

目的观察阿魏胶囊长期给药对大鼠血液学的影响。方法将SD大鼠200只随机分为4组(对照组与阿魏胶囊低、中、高剂量组),每组50只。给药组给予阿魏胶囊10.0、68.5、111.2 g生药/kg剂量灌胃;对照组给予等体积0.5%羧甲基纤维素钠(CMC-Na),于给药1个月、3个月、6个月和停药后1个月(恢复期)检测血液学指标。结果与对照组比较,阿魏胶囊高剂量组大鼠红细胞(RBC)、血红蛋白(HGB)、红细胞压积(HCT)均低于对照组(P<0.05),对血液学其他指标无明显影响(P>0.05)。停药1个月后可恢复。结论阿魏胶囊111.2 g生药/kg剂量长期给药对大鼠血液系统有一定的影响,不产生延迟毒性反应。

Objective To observe hematologic indexes of rat with A-Wei Capsule in chronic toxic test.Methods Two huandred rats were randomly divided into 4 groups： normal group,highdosage,middium dosage and low dosage A-Wei Capsule groups,50 rats per group.The test groups were administrated with contents of A-Wei Capsule by 10.0 g/kg,68.5 g/kg and 111.2 g/kg respectively,the control group was administrated by 0.5% CMC-Na.After 1 month,3 months,6 months and recovery period.Hematologic indexes were examined in each group.Results Red blood cell（RBC）,Hemoglobin（HGB）,haematocrit（HCT） of high dosage A-Wei Capsule group were lower than the control group（P0.05）,there were no significant differences in other hematologic indexes compared to the control group（P0.05）.Conclus-ion By long-term administration,111.2 g/kg A-Wei Capsule has some affection in hematologic indexes and can be recovered after 1 month with no administration.there was no delay toxic reaction.