经微导管肝癌化疗栓塞术治疗中晚期肝癌影响预后因素的分析

Value of microcatheter in the interventional treatment of advanced hepatocellular carcinoma

目的探讨中晚期肝癌的治疗方法及影响预后因素的分析。方法对136例中晚期肝癌患者行选择性肝动脉插管并经微导管内注射氟尿嘧啶、顺铂、羟基喜树碱,然后以碘油栓塞,随访6~36个月。观察肝癌栓塞前、后肿瘤大小、临床表现、血生化指标及并发症发生情况。结果 136例肝癌患者栓塞术后1、2、3、6、12个月肿瘤长度与宽度均较术前缩小（P〈0.05）,症状得到改善。栓塞术后1~4周甲胎蛋白均较术前降低（P〈0.05）。1年生存率为48.5%,2年生存率为8.0%,3年生存率为5.8%,中位生存期15个月。结论经微导管肝癌化疗栓塞术是治疗中晚期肝癌的有效方法。

Objective To investigate the efficiency of micro catheter in the treatment of advanced hepatocellular carcinoma by micro catheter in the interventional treatment.Methods One hundred and thirty six patients with advanced hepatocellular carcinoma were received transcatheter arterial chemoembolization.Fluorouracil,cisplatinhydroxy,camptothecin were injectd.All patients were followed-up for 6～36 months.The changes of tumor size were measured and compared before and after the embolization.ImagiologIy,biochemical index,the survival time,relative clinical symptoms and complications were observed.Res-ults In all cases,the tumor size significantly decreased after embolization（P0.05）.Alpha-fetoprotein,alpha fetoprotein（AFP） were significantly decreased after embolization（P0.05）,the survival rate of 1,2 and 3 years were 48.5%,8.0% and 6.2%.Medium survival times was 15 months.The clinical symptoms were significantly released.Conclusion Transmicrocatheter super hepatic arterial embolization is an effective and safe therapy for advanced advanced hepatocellular carcinoma.