三阴乳腺癌组织中VEGF、KAI-1、c-kit的表达及临床病理意义

Expression and clinical pathological significance of VEGF,KAI-1,c-kit in triple-negative breast cancer

目的探讨VEGF(vascular endothelial growth factor)、KAI-1(Kang Ai1,抗癌1号,CD82)、c-kit(CD117)在三阴乳腺癌组织中的表达及临床病理意义。方法应用免疫组织化学PV-9000法检测85例三阴乳腺癌(triple-negative breast cancer,TNBC)组织中VEGF、KAI-1、c-kit的表达。结果 (1)TNBC中VEGF阳性表达率为76.47%(65/85),VEGF表达在不同肿瘤大小各组间差异有统计学意义(P<0.05)。(2)TNBC中KAI-1阳性表达率为42.35%(36/85),KAI-1的表达在不同肿瘤大小、不同淋巴结转移情况、复发与否各组间差异有统计学意义(P<0.05)。(3)TNBC中c-kit阳性表达率为44.70%(38/85),c-kit的表达在不同肿瘤大小,不同临床分期,不同淋巴结转移情况各组间差异有统计学意义(P<0.05)。结论 VEGF阳性表达、KAI-1阴性表达、c-kit阴性表达均对三阴乳腺癌生长有一定意义,KAI-1和c-kit参与三阴乳腺癌转移,可以成为预测转移的参考指标。

Objective To explore the expression and clinical pathological significance of VEGF,KAI-1,c-kit in triple-negative breast cancer.Methods PV-9000 immunohistochemistry technique was applied to detect the expression of VEGF,KAI-1,c-kit in 85 triple-negative breast cancer cases.Results （1） The positive rate of VEGF was 76.47%（65/85） in TNBC.The expression of VEGF was associated with tumor size（P0.05）.（2） The positive rate of KAI-1 in TNBC was 42.35%（36/85）.The expression of KAI-1 was associated with size,metastasis of lymph nodes and recurrence（P0.05）.（3） The positive rate of c-kit in TNBC was 44.70%（38/85）.The expression of c-kit was associated with size,metastasis of lymph nodes and clinical stage（P0.05）.Conclusion The positive expression of VEGF,the negative expression of KAI-1,the negative expression of c-kit may contribute to the growth of triple-negative breast cancer.KAI-1 and c-kit may play important roles in triple-negative breast cancer metastasis and might serve as a marker to predict metastasis.