Ullmann法合成N-(4-甲基苯基)四氢环戊基吲哚的工艺研究

Study on Synthesis of N-(4-methylphenyl)Tetrahydro-cyclopentyl Indole by Ullmann Condensation

以2,3-环戊基吲哚及对碘甲苯为原料,经过乌尔曼(Ullmann)缩合反应得到目的物。通过选择合适的溶剂、缚酸剂及使用新型的催化剂,可大大提高产品的收率。

Using 2,3-cyclopentyl indole and p-iodotoluene as raw material,the target product was synthesized by Ullmann condensation reaction.Yield of the product can be greatly improved by selecting suitable solvent,acid binding agent and catalyst.