原发性高血压患者血清1,25二羟维生素D水平的相关性研究

A Study on Serum 1,25(OH)2-vitamin D Level in Patients with Primary Hypertension

目的:探讨原发性高血压患者血清1,25二羟维生素D水平与健康人群的差异,及可能影响1,25二羟维生素D水平的因素。方法 :随机选取原发性高血压患者124例(高血压组)与血压正常的健康人58例(对照组),进行血肌酐、血清1,25-二羟维生素D、肾素、钙离子水平测定和对比分析。结果 :与对照组比较,高血压组的血肌酐水平显著升高[(81.91±30.75)μmol/L比(76.53±11.77)μmol/L]及肾素[(3.14±9.22)ng/ml.h比(0.43±0.22)ng/ml.h],差异具有统计学意义(均P<0.01),1,25-二羟维生素D水平降低[(38.72±8.02)pg/ml比(39.59±11.53)pg/ml],差异具有统计学意义(P<0.05)。两组的钙离子浓度无差异。Pearson分析显示血肌酐水平与血清1,25-二羟维生素D水平存在负相关(r=-0.15,P<0.05)。结论 :高血压患者的1,25二羟维生素D水平显著低于健康人群。

Objective To investigate the differences of serum 1,25（OH）2-vitamin D level between primary hypertension patients and healthy population and to explore the factors which may affect the 1,25（OH）2-vitamin D level.Methods 124 patients randomly selected with primary hypertension were classified as hyprtension group,58 healthy volunteers with normal blood pressure were classified as control group.The Serum creatinine,serum 1,25（OH）2-vitamin D,renin,calcium ion levels were measured and compared between the two groups.Results The levels of serum creatinine in hyprtension group were significantly higher than those in Control Group [（81.91±30.75）μmol/L vs（76.53±11.77）μmol/L,P0.01].The levels of renin in hypertension group were significantly higher than those in control group [（3.14±9.22）ng/ml/h vs（0.43±0.22）ng/ml/h,P0.01].The serum 1,25（OH）2-vitamin D concentration in Hyprtension Group were lower than those in control group [（38.72±8.02）pg/ml vs（39.59±11.53）pg/ml,P0.05].There was no difference with calcium concentration in two groups.Pearson analysis showed that serum creatinine levels were negatively correlated with serum 1,25（OH）2-vitamin D levels.Conclusions The serum 1,25（OH）2-vitamin D concentration in primary hypertension patients was significantly lower than that in healthy population.Hypertension may affect renal function and then indirectly lead to the reduction of 1,25（OH）2-vitamin D level.