原发性肾病综合征医院感染临床分析

Clinical analysis of nosocomial infection in primary nephrotic syndrome

目的探讨原发性肾病综合征（PNS）医院感染的临床特征及相关因素,为完善防治措施提供依据。方法对2006~2010年收治的314例PNS患者按其发生医院感染与否,分为感染组与非感染组,对两组患者的临床特征进行回顾性分析。结果 314例患者中,医院感染发生率为17.83%;感染组与非感染组在性别、年龄、外周血白细胞计数、血红蛋白、血清胆固醇、血清球蛋白I、gAI、gM和治疗方案（单用激素、合用激素与免疫抑制剂、激素每日最大用量）方面均无显著性差异（P〉0.05）;感染组24小时尿蛋白定量和血清肌酐水平显著高于非感染组（P〈0.05）,住院时间比非感染组明显延长（P〈0.05）;感染组血清白蛋白水平和IgG水平显著低于非感染组（（P〈0.05）。结论 PNS医院感染的发生与否可能与血清肌酐、血清白蛋白I、gG和住院时间有关。

Objective To explore the clinical features and related factors of nosocomial infection in patients with primary nephrotic syndrome（PNS）,and to provide a reliable basis for prevention and treatment.Methods Clinical manifestations of 314 cases of PNS with nasocomial infection were retrospectively analyzed.Results The incidence of nasocomial infection in 314 cases of PNS was 17.83%.No significant difference were observed of gender,age,WBC of peripheral blood,hemoglobin,serum cholesterol,serum globulins,IgA,IgM and therapeutic regimes（steroids alone,combination of steroids and immunosuppressive agent,maximum of steroids qd） in PNS with or without nasocomial infection（P0.05）.The levels of serum creatinine and 24h proteinuria in PNS with nasocomial infection were significant higher than those in PNS without nasocomial infection（P0.05）.The length of hospital stay were longer in PNS with nasocomial infection（P0.05）.The levels of serum albumin and IgG in PNS with nasocomial infection were significant inferior to those in PNS without nasocomial infection（P0.05）.Conclusion The incidence of nosocomial infection in PNS was likely related to serum creatinine,serum albumin,IgG and length of hospital stay.