乳果糖预防上消化道出血后诱发肝性脑病的临床观察

Effect of lactulose on prevention of upper gastrointestinal hemorrhage of hepatic encephalopathy

目的观察乳果糖预防肝硬化患者上消化道出血后诱发肝性脑病的疗效。方法将36例因乙肝肝硬化、丙肝肝硬化、酒精性肝硬化、不明原因的肝硬化出现消化道出血的患者,随机分为观察组和对照组各18例,观察组予乳果糖溶液10~30ml,3次/日口服;对照组常规治疗,一周后观察疗效。结果观察组2例发生肝性脑病,发生率11.1%;对照组5例发生肝性脑病,发生率27.8%,观察组效果明显优于对照组组,差异有统计学意义（P〈0.05）。结论乳果糖是肝硬化患者上消化道出血后预防肝性脑病的有效方法,可常规预防应用。

Objective To analyze the effect of lactulose on revention of upper gastrointestinal hemorrhage of hepatic encephalopathy.Methods 36 cases were randomly divided into two groups including treatment group treated with lactulose solution and control group treated with conventional therapy.The effects were observed.Results There were 2 cases（11.1%） and 5 cases（27.8%） with hepatic encephalopathy in treatment group and control group.The effect of treatment group and control group was statistical different.Conclusion It if effective to prevent upper gastrointestinal bleeding in cirrhotic patients with hepatic encephalopathy with lactulose.