卡介菌多糖核酸和特异性免疫治疗对哮喘儿童肺功能和血清IgE的影响

The effects of polysaccharide nucleic acid fractiion of bacillus calmette guerin and specific immunotherapy on pulmonary function and serum IgE in asthmatic children

目的研究卡介菌多糖核酸(BCG-PNA)和特异性免疫治疗(SIT)对哮喘儿童肺功能和血清IgE的影响。方法用BCG-PNA和SIT治疗42例哮喘儿童,治疗前后检测肺功能,用酶联免疫吸附试验检测血清IgE水平。结果 BCG-PNA、SIT能明显改善哮喘儿童肺功能FVC、FEV1、V25等指标,BCG-PNA还能降低血清IgE水平。两者联合治疗比SIT治疗降低血清IgE更明显。结论 BCG-PNA和SIT能改善哮喘儿童肺功能,两者联合治疗对降低血清IgE有协同作用。

Objective This research aimed to explore the effects of polysaccharide nucleic acid fraction of Bacillus calmette Guerin（BCG-PNA） and specific immunotherapy（SIT） on pulmonary function and serum IgE in asthmatic children.Methods Before and after treatments with BCG-PNA and SIT,pulmonary function of 40 asthmatic children was analyzed.The serum IgE was detected by ELISA.Results BCG-PNA and SIT could improve FVC,FEV1 and V25 of pulmonary function indexes.BCG-PNA decreased serum IgE.Combination of these two treatments reduced serum IgE compared with SIT.Conclusion Both BCG-PNA and SIT can improve pulmonary function of asthmatic children.Combination of them has stronger effect in reducing serum IgE.