387例肺穿刺组织病理分析

Clinicopathological analysis of lung puncture biopsy

目的探讨肺穿刺组织的病理特点,提高肺穿刺病理的肺癌诊断率。方法回顾性分析387例肺穿刺病例的常规HE染色及部分病例的免疫组织化学染色结果,分析其临床病理特征。结果 387例肺穿刺病例中,见恶性病变284例(73.39%),其中以腺癌最多见;良性病变81例(20.93%),其中以炎症居多;见血凝快坏死样物22例(5.68%)。138例HE染色难以诊断病例的免疫表型分析见癌113例。结论肺穿刺组织活检是筛选肺癌简单、有效的方法,免疫组织化学染色、穿刺技术的改进及制片过程的优化能提高肺穿刺组织的肺癌诊断率。

Objective To explore the pathological features of lung biopsy and promote the development of clinical lung puncture technique to improve the rate of lung cancer diagnosis in lung biopsy.Methods The HE and immunohistochemical staining results of 387 cases lung biopsy specimens were retrospectively analyzed.The clinical pathological features were analyzed.Results There were 284 cases（73.39%） malignant lesions in 387 lung biopsy specimens,of which adenocarcinoma was the most common.And there were 81 cases（20.93%） benign lesions,of which the majority cases were inflammation.22 cases（5.68%） clot necrosis material were found.The phenotype analysis of 138 cases that won＇t diagnosed exactly showed 113 cases with lung cancer.Conclusion The lung tissue biopsy is a simple,effective method to screen lung cancer.With the immunohistochemistry,improvement of puncture technique and optimization of production processes,the diagnosis rate of lung cancer will be improved significantly.