多种肿瘤标志物联合检测对乳腺癌诊断的临床意义

The Clinical Significance of Combination Detection of Multiple Tumor Markers in Breast Cancer Diagnosis

目的探讨CA153、CA125及CEA单独及联合检测乳腺癌的临床意义。方法免疫化学分析仪分别检测乳腺癌患者(65例)、乳腺良性疾病组(60例)及正常女性体检者(75例)血清中CA153、CA125及CEA浓度。结果乳腺癌组血清中CA153、CA125及CEA浓度及阳性率显著高于良性疾病组及正常对照组,差异具有统计学意义(P<0.05);良性疾病组与正常对照组间无显著性差异;单独检测时CA153灵敏度最高,三种指标联合检测可明显提高乳腺癌诊断的灵敏度。结论 CA153、CA125及CEA联合检测可明显提高乳腺癌诊断的敏感性,对临床早期诊断具有一定的参考意义。

Objective To evaluate the clinical significance of separate and combination detection of serum tumor markers CA153,CA125 and CEA in patients with breast cancer. Methods Serum levels of the three tumor markers CA153,CA125 and CEA were detected by chemiluminescence in the 65 patients with breast cancer,60 patients with benign breast disease and 75 normal healthy people. Results The serum levels and positive rates of the three tumor markers were detected by chemiluminescence in breast cancer group were obviously higher than those in the benign breast disease group and normal ontrol group,there was statistically significant difference（P 0.05）;there was no significant difference between benign disease group and normal control group;the sensitivity of CA153 in alone detection was highest,the combination detection of three tumor markers could significantly improve the sensitivity of breast cancer diagnosis. Conclusion The combination detection of the three tumor markers CA153,CA125 and CEA can significantly improve the sensitivity of breast cancer diagnosis,which provides some reference for early clinical diagnosis.