65岁以上下呼吸道感染患者嗜肺军团菌抗体检测的调查分析

Investigative Study on the Antibody from Patients Infected by Legionella Pneumophila in Low Respiratory Tract over 65 Years Old

目的了解65岁以上的下呼吸道感染老年患者嗜肺军团菌(LP)感染情况。方法选取≥65岁的下呼吸道感染患者606例,男365例,女241例,年龄65岁至110岁,用间接免疫荧光法(IFA)检测其血清中嗜肺军团菌1型IgM(LP1-IgM)抗体。结果 606例的下呼吸道感染老年患者血清标本,检出阳性标本103例,阳性率17%。其中男365例(阳性率15.8%),女241例(阳性率18.7%),不同性别差异无显著性。从LP1年龄组间感染率比较无统计学意义(χ2=1.447,P>0.05)。感染率存在季节差异,夏﹑秋季感染率高于春﹑冬季。结论 65岁以上的下呼吸道感染患者有一定的LP感染率,且为易感人群,不同年龄LP感染率无显著性差异,临床应重视嗜肺军团菌的实验室依据,合理诊治。

Objective To study the situation of legionella pneumophila（LP） of low respiratory infection in elderly patients over 65 years old. Method 606 patients over 65 years old with the diagnosis of low respiratory infection were selected in the study,365 males,241 females,aged from 65 to 110 years old. Serum antibody（IgM） of LP1（LP1-IgM） was detected by indirect immunofluorescence assay（IFA） . Result In the serum samples of 606 cases,103 cases were detected positive,and the positive rate was 17%. 365 of them were male（positive rate：15.8%） . 241 of them were female（positive rate：18.7%） . Different sexes did not affect the results significantly. The infection rates between varied age groups had not showed statistical difference（χ2 = 1.447,P 0.05） . Analysis demonstrated that the infection rates were different between four seasons. The infection rates of summer and autumn were higher than those of spring and winter. Conclusion The patients with low respiratory infection over 65 years old have a high LP infection rate to a certain extend,who are susceptible group. The infection rates of patients from varied age groups have no significant difference. The doctors should pay enough attention to the clinical laboratory evidence of LP and make rational diagnosis.