环境内分泌干扰素对人类健康和生殖发育的影响

Effects of Environmental Endocrine Disruptors on Human Health and Reproductive Development

内分泌是调节机体生长、发育、生殖及行为的系统,不仅与人类行为有直接关系,而且还直接影响生殖细胞的生长成熟。环境内分泌干扰素与激素结构类似,只需很小剂量即可产生危害性后果,并有蓄积作用,对人类健康产生持久影响。大量流行病学调查、实验室动物研究、人类细胞和组织研究证据显示,环境内分泌干扰素可能引起基因突变、细胞破坏,尤其在生长发育的关键时期,对人类生殖系统、胚胎发育均有影响,可引起出生缺陷或癌症等。综述环境内分泌干扰素特性、作用机制及其对胚胎发育和对人类健康的影响,目的是为提高出生人口素质和人类的生命质量,预防和降低环境内分泌干扰素污染对人类的危害提供依据。

Endocrine is a system of hormones that regulates an organism＇s development,growth,reproduction and behavior,which plays an important role in human behavior and development of the fertilized eggs.Environmental endocrine disruptors（EEDs） have a similar structure with natural hormones which might mimic natural hormones and bind with endocrine receptors,producing unnatural outcomes,resulting in a permanent adverse effect on human body after accumulation.An increasing body of evidence from animals and humans indicates that EEDs may cause gene mutation and cell disruption,especially at the significant stage of embryonic development,influencing on reproductive system,and embryonic development,even lead to congenital malformation or cancer in human.This paper reviews the characteristics,mechanism of EEDs,its influencing on embryonic development,and preventive measures for human health.The purpose is to provide the evidences for prevention and reducing of EEDs pollution,and improve the quality of birth population and human life.