蜕膜化子宫内膜间质细胞细胞骨架重塑研究进展

Cytoskeleton Reorganization of Endometrium Stromal Cell During Decidualization

子宫内膜蜕膜化是成功妊娠的重要环节。蜕膜化可参与获得子宫内膜容受性。研究发现,早期胚胎着床失败与子宫内膜蜕膜化受损有关。蜕膜化涉及子宫内膜间质细胞细胞骨架重塑,包括中间纤维丝、微丝和微管等各种骨架成分的变化,以及相关骨架结合蛋白对骨架动态变化的影响。就蜕膜化过程中的细胞骨架成分具体变化、性激素对蜕膜化细胞骨架调节以及细胞骨架变化对蜕膜化的自身调节进行综述。

Decidualization involved in endometrial receptivity is the important step during process of pregnancy.The injury of decidualization is associated with the early pregnancy loss.The cytoskeleton reorganization of the endometrial stromal cells related to the decidualization depends on the changes of cytoskeleton members such as intermediate filament,microfilament,microtubule and so on.It also refers to the cytoskeletal dynamic change regulated by skeleton binding protein.In this review,we discussed the cytoskeleton changes during decidualization,hormonal effect on cytoskeleton of the decidualizing endometrial stromal cells,as well as the autoregulation of decidualization once the cytoskeleton changes.