摘要
环境内分泌干扰化合物是指存在于生物的直接生存环境中,能够干扰生物正常内分泌并导致其功能异常的一些污染物,其中环境激素及其类似物对生物体的毒害影响最大。环境激素对生物个体的直接毒害作用包括生殖发育、神经内分泌、免疫系统及致癌致畸等方面,并且与发育源性疾病间有着密切的关系。表观遗传机制在环境激素的长期毒害效应——传代效应中始终发挥着重要作用。
Environmental endocrine disruptors are defined as some pollutants resided in the direct environment of organisms,which disrupt the normal endocrine function.Of these compounds,environmental hormones and their analogs can affect organisms enormously.In this review,we discussed the direct adverse effects of environmental estrogens,including the damages on reproduction and development,neuroendocrine,immune system,carcinogenic and teratogenic effects.And we introduced the relationship between environmental hormones and development-origin of adult diseases.Epigenetics always play a key role in the long periods adverse effects,transgenerational effects,of environmental estrogens.
出处
《国际生殖健康／计划生育杂志》
CAS
2011年第3期243-246,共4页
Journal of International Reproductive Health/Family Planning
基金
国家重大科学研究计划(973计划)项目(2009CB)
关键词
环境激素
毒害效应
发育源性成人疾病
传代效应
表观遗传
Environmental estrogens
Adverse effects
Development-origin of adult diseases
Transgenerational effects
Epigenetics
