还原型谷胱甘肽联合甘利欣治疗抗痨药物性肝损害的临床观察

THE CURATIVE EFFECTS OF THE COMBINED USE OF REDUCED GLUTATHIONE AND DIAMMONIUM GLYCYRRHIZINAT ON HEPATIC LESION CAUSED BY ANTITUBERCULOSIS DRUG

目的观察还原型谷胱甘肽对抗痨药物所致肝损害的疗效。方法将42例因抗痨治疗而致肝损害的患者随机分为治疗组(22例)和对照组(20例)。治疗组给予还原型谷胱甘肽与甘利欣,对照组给予甘利欣。比较两组的疗效。结果治疗组总有效率为90.91%,对照组总有效率为60%,两组比较差异有显著性(P<0.05)。结论还原型谷胱甘肽联合甘利欣治疗抗痨药物相关性肝损害疗效显著,值得临床应用。

Objective To observe the curative effects of reduced glutathione on hepatic lesion caused by antituberculosis drugs.Methods 42 cases of hepatic lesion caused by antituberculosis drugs were randomly divided into two groups.The 22 cases in the treatment group received reduced glutathione and diammonium glycyrrhizinate,while the 20 cases in the control group were only given diammonium glycyrrhizinate.The therapeutic effects of the two groups were compared.Results The total therapeutic rates in the treatment group and the control group were 90.91% and 60%（P0.05）.Conclusion The combined use of reduced glutathione and diammonium glycyrrhizinate can produced good therapeutic effects in treating hepatic lesion caused by antituberculosis drugs.