三种HP检测方法敏感性和特异性的比较

COMPARISON OF THE SENSITIVITY AND SPECIFICITY OF THREE HP DETECTION METHODS

目的探讨HP尿素酶抗体胶体金试验的临床价值。方法分别用HP尿素酶抗体胶体金试验、快速尿素酶试验及13C尿素呼气试验对217例因胃部不适接受胃镜检查的门诊和住院患者进行HP感染情况检测,分别计算其灵敏度及特异度。结果与13C尿素呼气试验比较,HP尿素酶抗体胶体金试验的灵敏度及特异度分别为81%、92%,快速尿素酶法的灵敏度及特异度分别为78%、89%。结论 HP尿素酶抗体胶体金试验结果更加直观快速,操作简便,敏感性高,特异性强,无需专用仪器和设备,尤其适用于人群流行病学调查。

Objective To explore the clinical value of helicobacter pylori（HP） urease antibody colloidal gold test.Methods 217 cases of gastroscopy because of stomach discomfort and hospital outpatient HP infection received HP urease antibody colloidal gold test,the rapid urease test and 13C-urea breath test respectively to calculate their sensitivity and specificity.Results Compared with the 13C urea breath test,the sensitivity and specificity of HP urease antibody colloidal gold test were 81% and 92% respectively,and the rapid urease test sensitivity and specificity were 78% and 89% respectively.Conclusion HP urease antibody colloidal gold test can give more direct-viewing and fast results,easy operation,high sensitivity and high specificity,therefore,no special equipment and facilities are needed,especially when used for epidemiological investigation.