LAP和β_2-MG在乙型肝炎肝硬化和酒精性肝硬化鉴别诊断中的应用

LAP and β_2-MG in the hepatitis B and alcoholic liver cirrhosis diagnosis of cirrhosis

目的探讨亮氨酸氨基肽酶(LAP)、β2-微球蛋白(β2-MG)在酒精性肝硬化和乙肝肝炎肝硬化患者鉴别诊断中的意义。方法用Olympus AU5400全自动生化仪检测30例酒精性肝硬化(ALC)患者和72例乙型肝炎肝硬化(HLC)患者血清中的丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、r-谷氨酰转肽酶(r-GT)、亮氨酸氨基肽酶(LAP)、β2-微球蛋白(β2-MG),计算AST/ALT比值并对检测结果进行统计学分析。结果 ALC患者血清中的LAP、r-GT活性和AST/ALT比值均高于HLC患者,β2-MG的含量低于HLC患者,差异有统计学意义(P<0.05)。LAP、r-GT、AST/ALT比值、β2-MG在ALC患者中的ROC曲线下面积(AUC)分别为0.727、0.702、0.698和0.685;阳性率分别为75.0%、70.1%、67.8%和68.9%,ALC患者的各项指标的阳性率分别高于HLC患者(P<0.01)。结论 LAP和β2-MG在酒精性肝硬化和乙肝肝炎肝硬化患者鉴别诊断中有一定的应用价值。

Objective Leucine aminopeptidase（LAP） ,β2-microglobulin（β2--MG）in alcoholic cirrhosis and hepatitis B liver cirrhosis differential diagnosis of patients. Methods The Olympus AU5400 automatic biochemical analyzer detected 30 cases of alcoholic liver cirrhosis（ ALC） patients and 68 cases of hepatitis B liver cirrhosis （HLC）in patients with serum alanine aminotransferase （ALT）, aspartate aminotransferase enzyme fAST）, r-glutamyl peptide enzyme phthalate switch （r-GT）, leucine aminopeptidase （LAP） ,β2- microglobulin（β2-MG） ,calculation of AST / ALT ratio and test results statistical analysis. Results ALC patients in the LAP,r-GT activity and AST / ALT ratio in patients were higher than HLC,β2- MG levels were lower than the HLC,the difference was significant（P〈0.05）. LAP, r-GT, AST/ALT ratio, 132-MG in the ALC patients in area under the ROC were 0. 727, 0. 702, 0. 698 and 0. 685 ;positive rates were 75.0% ,70.1% ,67.8% and 68.9% ,ALC patients were positive indicators than HLC patients （P〈0.01）. Conclusion LAP and β2-MG has some value in the alcoholic liver cirrhosis and the hepatitis B hepatitis liver cirrhosis patient differential diagnosis.