健康人群血清总胆红素和直接胆红素参考值范围的临床研究

Reference value for total bilrubin and direct bilrubin in healthy population

目的 研究建立排除血压、血脂高于正常参考值和胰岛素抵抗以及氧化应激状态的健康人群血清总胆红素（TBIL）和直接胆红素（DBIL）的正常参考值范围.方法 用矾酸盐法在日本奥林巴斯AU640全自动生化分析仪上测定本地区8 728例健康人血清TBIL和DBIL,采用SPSS 17.0统计软件,按年龄和性别分组进行统计学分析.结果 TBIL和 DBIL的正常参考值范围分别为：7.92～23.11、1.98～7.12 μmol/L;男女不同性别组的TBIL和DBIL检测值分别为：8.01～23.51、7.71～21.90,2.07～7.35、1.54～6.70 μmol/L范围.结论 胆红素有较强的抗氧化作用,胆红素处于低水平状态也具有重要的临床价值.因此,各地区建立健康人群的胆红素参考范围对于疾病的预防、诊断及治疗具有重要意义.

Objective To establish reference value for blood serum total bilrubin（TBIL）and direct bilrubi（DBIL）in healthy population without hypertension, hyperlipidemia, insulin resistance and oxidative stress in special occupations. Methods TBIL and DBIL of 8728 healthy person from this district were measured in vanadate oxidation method in Japan Olympus AU640 automatic biochemical analysis instrument,and all results were analysised by SPSS17.0 statistic software in the different group of age and sex. Results The reference value for TBIL and DBIL is 7.92-23.11,1.98-7.12 （μmol/L） ;the level of TBIL and DBIL in male and female group was 8.01-23.51,7.71-21.90, 2.07-7.35,1.54 6.70 （μmol/L）. Conclusion The bilrubin play importance role in stronger anti oxygenation,even to a low level, therefore, reference value for TBIL and DBIL should be established in every dis trict.