肥胖人群前列腺体积比较分析

Prostate volume in obesity people

目的探讨肥胖与男性良性前列腺增生（BPH）的关系。方法入选253例40岁以上健康体检男性，经询问病史，测身高、体重、腰围、体脂肪率、血压、空腹血糖、血脂及前列腺B超，排除肥胖相关性疾病，按体质指数（BMI）分为正常组（18．5～23．9kg／m^2）、超重组（24．0～27．9kg／m^2）及肥胖组（≥28kg／m^2），按腰围分为正常组（〈85cm）及腹型肥胖组（≥85cm），按体脂肪率分为正常组（≤25％）及超标组（〉25％），分析各组前列腺体积的差异，组间比较使用t检验及χ2检验。结果BMI正常组前列腺体积为（18．2±6．1）ml，超重组为（21．6±6．3）ml，肥胖组为（24．9±7．6）ml，正常组与超重组、肥胖组比较，差异有统计学意义。腰围正常组前列腺体积为（20．65．6）ml，腹型肥胖组为（23．5±6．2）ml，两组比较差异有统计学意义。体脂肪率正常组前列腺体积为（19．6±6．5）ml，超标组为（23．9±5．3）ml，两组比较前列腺体积差异有统计学意义。BMI、腰围及体脂肪率高的人群前列腺体积更大。BMI≥24kg／m^2人群中腰围正常或者体脂肪率正常人群，BPH发生率并无明显增高。结论肥胖是BPH的危险因素；腰围及体脂率超标者，发生BPH危险性更高。

Objective To investigate the association between obesity and benign prostate hyperplasia （BPH）. Methods A total of 253 men （ 〉 40 year-old） with no obesity-related diseases were selected. Medical history, height, body weight, waist circumference （ WC ）, body fat ratio, blood pressure, fasting blood glucose, blood lipid and prostate ultrasound were evaluated. The participants were then assigned to the normal group （body mass index 18.5 to 23.9 kg/m2） ,overweight group （24. 0 to 27. 9 kg/m2） and obesity group （ ≥ 28 kg/m2 ）. The subjects were also divided into the normal group （ WC 〈 85 cm ） and abdominal obesity group （WC ≥ 85 cm） or normal group （body fat ratio ≤25% ） and excessive body fat ratio group （ 〉 25% ） . Prostate volume was analyzed in each group. Results The prostate volume was significantly different between the normal body mass index group and overweight or obesity groups, normal WC group and abdominal obesity group, and normal body fat ratio group and excessive body fat ratio group. The prostate volume was increased in individuals with higher body mass index, WC and body fat ratio. Of those with body mass index≥24 kg/m2 and normal WC or body fat ratio,the incidence of BPH was not significantly increased. Conclusion Obesity may be a risk factor for BPH; individuals with increased WC and body fat ratio may have a higher risk of BPH.