含缓释淀粉的肠内营养对重症急性胰腺炎病人预后的影响

The enteral nutrition containing slow release starch improves the outcome of severe acute pancreatitis patients

目的:探讨含缓释淀粉的肠内营养对重症急性胰腺炎(SAP)病人的影响。方法:选择接受EN治疗的SAP病人180例,随机分为研究组和对照组,每组各90例,分别给予同等热量的EN支持,研究组用含缓释淀粉的瑞代,对照组用瑞素,观察EN支持前和支持后第10天病人空腹血糖(FBG)、餐后2 h血糖(2h BG)、糖化血红蛋白(HbA1c)的变化。并比较两组病人感染率、并发症发生率、住院时间和病死率的差异。结果:在营养支持后第10天,研究组病人FBG、2h BG、HbA1c水平均明显低于对照组(P<0.05)。研究组病人的感染率、并发症发生率明显低于对照组(P<0.05),住院时间亦明显短于对照组(P<0.05),病死率无显著性差异(P>0.05)。结论:含缓释淀粉的EN应用于SAP病人显著优于标准配方的EN制剂。

Objective： To evaluate the impacts of enteral nutrition contained with slow release starch in severe acute pancreatitis（SAP） patients. Methods： 180 cases of SAP patients were randomly divided into slow release starch group（Fresubin diabetes,SSPC,n=90） and control group（Fresubin,SSPC,n=90）.The fasting blood glucose（FBG）,2-hour postprandial blood glucose（2h BG） and glycosylated hemoglobin（HbA1c） were examined at base line and 10 days after nutrition support.The infectious rates,complication rates,mortality and hospital stay were compared between the two groups.Results： FBG,2h BG and HbA1c were significantly lower in slow release starch group than control group（P0.05）10 days after nutrition treatment.The infectious rate and complication rate were also significantly lower compared with control group（P0.05）.The mortality rate was not significantly different between the two groups（P0.05）,and the hospital stay in slow release starch group was shorter than control group（P0.05）.Conclusion： Enteral nutrition contained with slow release starch is the preferred enteral nutrition in severe acute pancreatitis（SAP） patients.