H5N1大流行流感疫苗的研究进展

Progress in Research on Pandemic Influenza H5N1 Vaccine

高致病性H5N1流感病毒可导致严重的致死性疾病,对人类健康造成了极大威胁。尽管目前尚未发生人与人之间传播,但该病毒一旦与人流感病毒重组,即有可能转变为可在人与人之间传播的高致死性流感病毒,从而导致新的流感大流行。此外,H5N1流感病毒经过不断变异后可突破种属屏障,从禽类传播给哺乳动物及人类,并进一步在病毒和宿主的多种因素作用下导致宿主发病乃至死亡。本文对H5N1大流行流感疫苗的研究进展作一综述。

Highly pathogenic avian influenza H5N1 virus may cause serious fatal diseases and constitute a grave threat to human health.Although the current H5N1 influenza strains appear not to be transmissible from human to human,it is of major concern that mixing with human influenza strains could convert H5N1 to a strain that would spread that would spread from human to human and cause a serious pandemic.In addition,avian influenza H5N1 virus after continuous variation may break through the species barrier and spread to mammals and humans,thereby cause disease even death under the influence of various virus and host factors.This paper reviews the progress in research on pandemic influenza vaccine.