摘要
MicroRNAs(miRNAs) are a class of highly abundant non-coding RNA molecules that are involved in several biological processes.Many miRNAs are often deregulated in several diseases including cancer.There is substantial interest in exploiting miRNAs for therapeutic applications.In this editorial,we briefly review current advances in the use of miRNAs or antisense oligonucleotides(antagomirs) for such therapies.One of the key issues related to therapy using miRNAs is degradation of naked particles in vivo.To overcome this limitation,delivery systems for miRNA-based therapeutic agents have been developed,which hold tremendous potential for improving therapeutic outcome of cancer patients.
MicroRNAs （miRNAs） are a class of highly abundant non-coding RNA molecules that are involved in several biological processes. Many miRNAs are often deregulated in several diseases including cancer. There is substantial interest in exploiting miRNAs for therapeutic applications. In this editorial, we briefly review current advances in the use of miRNAs or antisense oligonucleotides （antagomirs） for such therapies. One of the key issues related to therapy using miRNAs is degradation of naked particles in vivo. To overcome this limitation, delivery systems for miRNA-based therapeutic agents have been developed, which hold tremendous potential for improving therapeutic outcome of cancer patients.
基金
supported by grants from the National Institutes of Health(CA109298,CA110793,CA128797,RC2GM092599,U54 CA151668)
Department of Defense(OC073399,OC093146,BC085265)
a Program Project Development Grant from the Ovarian Cancer Research Fund,Inc,the Ward Family
the Zarrow Foundation
the Marcus Foundation,the M.D.Anderson Cancer Center SPORE in Ovarian Cancer(P50 CA083639)and Uterine Cancer(P50 CA098258)
the Laura and John Arnold Foundation,and the Betty Ann Asche Murray Distinguished Professorship
