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胆道闭锁肝纤维化相关研究的回顾与展望 被引量：8

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摘要 胆道闭锁（Biliary Atresia）是导致婴幼儿终末期肝病的最常见原因,也是目前儿童肝移植的第一位适应症.该疾病以肝内外胆道的纤维闭塞性病变为特点,常迅速引起胆汁性肝硬化而导致患儿死亡,患儿平均生存时间仅19个月[1].法国巴黎Bicetre医院小儿外科曾对271例行Kasai手术或其变异术式的胆道闭锁患儿进行了长达20年的随访,结果仅有63例（23%）患者带自体肝脏长期生存,而其中的61例肝穿刺活检提示存在不同程度的肝硬化表现[2].
作者 邓盼墨（综述） 郑珊（审校）
机构地区 复旦大学附属儿科医院
出处 《临床小儿外科杂志》 CAS 2011年第1期59-61,共3页 Journal of Clinical Pediatric Surgery
关键词 胆道闭锁 肝纤维化 胆汁性肝硬化 终末期肝病 闭塞性病变 肝穿刺活检 小儿外科 生存时间
分类号 R726.574 [医药卫生—儿科]
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  • 1Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book..Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis[J].World Journal of Gastroenterology,2001,7(3):363-369. 被引量：73
  • 2病毒性肝炎防治方案（试行）[J].中华传染病杂志,1995,13(4):241-247. 被引量：1767
  • 3[1]Paul K,Tam H.Cholangitis After Hepatic Portoenterostomy For Biliary Atresia:A Multivariate Analysis Of Risk Factors[J].J Pediatr,2003,142:566-571.
  • 4[2]E T Wu,H L Chen,Y H Ni,et al.Bacterial cholangitis in patients with biliary atresia:impact on short-term outcome[J].Pediatr Surg Int,2001,17:390-395.
  • 5[3]C S Hsieh,L T Huang,C C Huang,et al.Bacteria ascend to liver from the bilioenteric conduit after choledochojejunostomy in the cholestatic rat[J].Pediatr Surg Int,2003,19:699-702.
  • 6[4]J H Chuang,S Y Lee,W J Chen,et al.Changes in Bacterial Concentration in the Liver Correlate with That in the hepaticojejunostomy after Bile Duct Reconstruction:Implication in the Pathogenesis of Postoperative Cholangitis[J].World J.Surg,2001,25:1512-1518.
  • 7[5]Kawarasaki H,Itoh M,Mizuta K,et al.Further observations on cystic dilatation of the intrahepatic biliary system in biliary atresia after hepatic portoenterostomy:report on 10 cases[J].Tohuku J Exp Med,1997,181:175-183.
  • 8[6]Jiin-Haur Chuang,Shin-Ye Lee,Chie-Song Shieh,et al.Reappraisal of the role of the bilioenteric conduitin the pathogenesis of postoperative cholangitis[J].Pediatr Surg Int,2000,16:29-34.
  • 9[7]M.Yagi,M.Iwafuchi,M.Uchiyama,et al.Electromyographic study of the mechanism of postoperative cholangitis in congenital biliary atresia Intestinal motility after Roux-en-Y biliary reconstruction[J].Pediatr Surg Int,1990,5:433-436.
  • 10[8]Tagge DU,Tagge EP,Drongowski RA,et al.A long-term experience with biliary atresia.Reassessment of prognostic factors[J].Ann Surg,1991,214:590-598.

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临床小儿外科杂志
2011年 第1期

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