β-淀粉样肽40／42与2型糖尿病及动脉粥样硬化的关系

Association of β-amyloid peptide 40/42 with type 2 diabetes mellitus and atheroselerosis

检测2型糖尿病、动脉粥样硬化（AS）患者血清β-淀粉样肽（AB）40和Aβ42水平。结果显示，Aβ40在糖尿病组高于对照组：（274．70±159．51对162．63±87．58）pg／ml，P〈0．05]，糖尿病合并As组升高更显著：（616．95±195．13）pg／ml，P〈0．01]；单纯As组Aβ40水平也明显高于对照组i（318．52±188．65）pg／ml，P〈0．05]．提示Aβ40是2型糖尿病合并As的危险因素。而各组间Aβ42水平差异无统计学意义。

[ Summary] Serum β-amyloid peptide （Aβ） 40 and Aβ42 levels in patients with type 2 diabetes mellitus （ T2DM ）and atherosclerosis（AS） were detected by ELISA. The results showed that serum Aβ40 level in T2DM group was significantly higher than that in the eontrol group [ （274.70 ± 159.51 vs 162.63± 87.58 ） pg/mt, P 〈 0.05 1, especially in the diabetic patients aecompanied with AS[ （616.95±195.13） pg/ml,P〈0.01 1. Serum Aβ40 level in simple AS group was also higher than that in control group [ （ 318.52 ±188.65 ） pg/ml, P〈0.05 ]. These results suggest that Aβ40 is a risk factor of T2DM complicated with AS. However, there was no difference in serum Aβ42 levels among various groups.