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心房颤动和基因多态性的研究进展 被引量：4

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摘要 利用基因相关分析及基因定位克隆等技术,越来越多的研究发现心房颤动(简称房颤)发病与多个基因的多态性有关,这些基因主要包括编码心肌细胞离子通道基因,包括钾离子相关通道KCNN3和Ik-Ach基因,钠离子相关通道SCN5A基因和钙离子相关调控蛋白SLN基因。还发现一些非离子通道蛋白基因,如肾素-血管紧张素-醛固酮系统相关基因、炎症相关基因、NPPA基因和ZFHX3基因等多态性也与房颤发生有一定的相关性,随着分子生物学技术的发展和人类基因组学研究的深入,人们逐步认识到单核苷酸多态性在房颤病因学中所起的重要作用。
作者 沈才杰 陈晓敏
机构地区 宁波大学
出处 《中国心脏起搏与心电生理杂志》 北大核心 2011年第3期202-205,共4页 Chinese Journal of Cardiac Pacing and Electrophysiology
关键词 心血管病学 心房颤动 综述 单核苷酸多态性 基因
分类号 R541.75 [医药卫生—心血管疾病]
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参考文献28

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同被引文献52

  • 1曾治宇,王方正,浦介麟.基因与心律失常[J].中国心脏起搏与心电生理杂志,2004,18(3):227-230. 被引量：1
  • 2陈炜,朱立光.肾素-血管紧张素系统与心房颤动关系的研究进展[J].心血管病学进展,2007,28(3):438-441. 被引量：4
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  • 7Yang Y, Xia M, Jin Q, et al. Identification of a KCNE2 gain-of- functionmutation in patients with familial atrial fibrillation[ J]. Am J Hum Genet,2004,75:899.
  • 8Xia M, Jin Q, Bendahhaou S, et al. A Kir2.1 gain-of-function mu- tation underlies familial atrial fibrillation[J]. Biochem Biophys Res Commun, 2005,332:1 012.
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  • 10Olson TM, Alekseev AE, Liu XK, et al. Kvl. 5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation [J]. Hum Mol Genet, 2006,15:2 185.

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中国心脏起搏与心电生理杂志
2011年 第3期

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