托烷司琼复合地塞米松预防全身麻醉甲状腺切除术后恶心呕吐的临床观察

Tropisetron compound dexamethasone after general anaesthesia of thyroidectomy to prevent nausea and vomiting of clinical observation

目的观察5-HT3受体拮抗剂托烷司琼复合地塞米松预防全身麻醉甲状腺切除术后恶心呕吐(PONV)的临床效果。方法择期全身麻醉手术100例,随机双盲分成托烷司琼组(A组)和托烷司琼复合地塞米松组(B组),每组50例。术毕A组静脉注射托烷司琼3mg,B组静脉注射托烷司琼3mg加地塞米松5mg。记录麻醉时间和手术时间;随访并记录术后24h有无恶心呕吐及程度。结果 2组恶心呕吐等级明显不同,B组主要为0～Ⅰ度,B组恶心呕吐等级低于A组,差异有显著性(P<0.05)。结论托烷司琼复合应用地塞米松比单独应用托烷司琼对全身麻醉后甲状腺切除恶心呕吐抑制更明显,是一种经济、有效、安全的止吐方法。

【Objective】 To view after general anaesthesia of thyroidectomy to prevent nausea and vomiting of clinical results.【Methods】 A randomized,double-blind method,100 patients undergoing thyroidectomy were divided into two groups of patients with tropisetron group（A group）,tropisetron compound dexamethasone group（B group）,50 cases of each group.After surgery,A group was injected tropisetron 3 mg;B group was injected tropisetron 3 mg with dexamethasone 5 mg.To record the time of anaesthsia and surgey;Observation of the two groups within 24 h few cases of nausea and vomiting occurred in the extent of the problem.【Results】 Nausea and vomiting were significantly different levels,B group mainly 0~Ⅰgrade,nausea and vomiting grade group B than group A,there was a significant difference.【Conclusion】 Tropisetron compound dexamethasone than tropisetron alone inhibition of nausea and vomiting even more evident,was a kind of economic effective safe method.