健脾复方联合化疗治疗大肠癌术后患者的临床疗效观察

Observation of Jianpi Compound Recipe combined with chemotherapy in post- operation colorectal cancer patients

目的观察健脾复方联合化疗治疗大肠癌术后患者的疗效、生活质量和安全性。方法选择2005年1月～2009年6月在上海市中医医院就诊的大肠癌术后患者,共66例大肠癌患者纳入观察,给予健脾复方联合化疗(联合治疗组)或健脾复方(中药组)治疗。采用前瞻性队列研究,比较患者的生存率、生活质量和实验室检查指标。结果随访期间共有22例患者(33.3%)死亡,其中联合治疗组8例(8/37,21.6%),中药组14例(14/29,48.3%)[相对危险度(RR)=0.45,95%可信区间:0.22～0.92]。经log-rank检验,联合治疗组与中药组的生存状态差异有统计学意义(P=0.040 9)。两组病人治疗前后生活质量评分差异无统计学意义(P>0.05)。联合治疗组治疗后除白细胞计数和中性粒细胞计数低于中药组(P<0.05),血红蛋白水平和白蛋白水平高于中药组(P<0.05)外,其余实验室指标比较差异无统计学意义。结论健脾复方联合化疗治疗大肠癌术后患者可提高患者生存率,减少贫血,促进血清白蛋白合成。

Objective To observe efficacy,quality of life,and safety of Jianpi Compound Recipe combined with chemotherapy in post - operation colorectal cancer patients.Methods A prospective analysis was used.All were post - operation colorectal cancer patients of Shanghai Municipal Hospital of Traditional Chinese Medicine from January 2005 to June 2009.Patients received Jianpi Compound Recipe combined chemotherapy（Combined Treatment Group） or Jianpi Compound Recipe （TCM Group）.Patient survival,quality of life and laboratory parameters were compared.Results Totally 66 patients were enrolled in the study.Thirty - seven were in Combined Treatment Group,29 were in TCM Group.Twenty -two patients（33.3%） died during follow - up.Among them,8（8/ 37,21.6%） were from Combined Treatment Group,14（14/29,48.3%） were from TCM Group （RR=0.45,95%CI：0.22-0.92）.The survival rate of two groups was significantly different（by log - rank test,P = 0.040 9 ）.There was no significant difference of quality of life scores between two treatments（P0.05）.The white blood cell count and neutrophilic granulocyte count were lower,albumin level and hemoglobin level were higher in Combined Treatment Group compared with TCM Group（P0.05,respectively）.Conclusion Jianpi Compound Recipe combined with chemotherapy could achieve higher survival rate,reduce anemia,promote synthesis of albumin.