肝癌术后抗乙型肝炎病毒治疗对预防肝癌复发的研究

Liver cancer treatment after surgery for prevention of hepatitis B virus recurrence of liver cancer

目的探讨肝癌手术后抗乙型肝炎病毒(HBV)治疗对预防肝癌复发的效果及影响。方法将20例并发乙型肝癌病毒复制的肝癌患者随机分为两组:对照组10例,单纯接受了肝癌根治术;治疗组10例,在肝癌根治术后应用拉米夫定进行抗病毒治疗。观察比较两组患者肝功能,HBV DNA定量,Child-pugh积分及生存率。结果治疗组较对照组肝功能改善明显(P<0 01);术后12月月个时,治疗组HBV DNA定量水平及Child-pugh评分明显小于治疗1个月时及对照组,差异有统计学意义(P<0.01)。治疗组平均生存时间为(23.4±2.2)个月,明显高于对照组(15.1±2.1)个月,差异有统计学意义(P<0.01)。结论肝癌术后给予抗HBV治疗对预防肝癌复发效果良好。

Objective To investigate the anti _ hepatitis B virus after liver surgery to prevent recurrence of liver cancer treatment effects and impact.Methods Twenty cases with hepatitis B virus replication in liver cancer liver cancer were randomly divided into two groups：control group （n = 10） for radical resection of hepatocellular carcinoma only;treatment group（n = 10） for liver cancer after radical resection of lamivudine antiviral therapy.Liver function,HBV DNA quantification, Child-pugh score and survival of the two groups were observed and compared.Results In the treatment group,the liver function improved more significantly than the control group（F0. 01）;12 months later,the treatment group＇s quantitative HBV DNA levels and Child - pugh score were significantly lower than those in January and of the control group.There was significant difference （P0.01）.The average survival time of treated group was（23.4±2.2） months,significantly higher than the control group（15.1±2.1） months.The difference was statistically significant （P0.01）.Conclusion The effect of anti - hepatitis B virus after liver surgery to prevent recurrence of liver cancer is obvious.