恩度胸腔灌注治疗恶性胸腔积液的作用研究

The effect of intrapleural injection of endostar on malignant pleural effusion

目的比较治疗前良、恶性胸腔积液中VEGF、IL-8水平,研究恩度胸腔灌注治疗恶性胸腔积液的客观疗效。方法选取60例胸腔积液患者,分为肺癌组40例,良性病变组20例,治疗前分别检测胸水VEGF和IL-8水平。良性病变组予抗感染治疗后胸水吸收;肺癌组予恩度胸腔灌注治疗,治疗后行胸水VEGF及IL-8含量测定。结果治疗前肺癌组胸水VEGF与IL-8水平显著高于良性病变组(P<0.01)。肺癌组恩度治疗后较治疗前胸水VEGF与IL-8水平显著下降(P<0.01),其中完全缓解(CR)2例,部分缓解(PR)3例,稳定(SD)30例,和进展(PD)5例,疾病控制率87.5%。结论恩度胸腔灌注治疗恶性胸腔积液是一种安全、可行的手段,有较好的近期疗效,为恶性胸腔积液的综合治疗提供了种新的思路,值得进一步研究。

Objective To compare the difference of expression levels of VEGF and IL-8 between benign pleural effusions（BPE） and malignant pleural effusions（MPE） before treatment and to explore the clinical efficacy of endostar on MPE.Methods Sixty patients of pleural effusions were divided into lung cancer group（n=40） and benign disease group（n=20）,and the expression levels of VEGF and IL-8 were accessed before treatment.Intrapleural injection of endostar was performed on lung cancer patients,and then the expression levels of VEGF and IL-8 were accessed.Results The expression levels of VEGF and IL-8 in MPE were significantly higher than those in BPE（P0.01）.In lung cancer group,the expression levels of VEGF and IL-8 after-treatment significantly decreased after treatment（P0.01）.Of the 40 MPE patients,2 cases were CR,3 cases were PR,30 cases were SD,5 cases were PD,and the therapeutic effective rate was 87.5%.Conclusion Intrapleural injection of endostar is a safe and feasible way to treat MPE.It is worthy of clinical generalization and further clinical observation.