复方甘草酸单胺S联合雷公藤多甙治疗慢性湿疹引起嗜酸性粒细胞增多疗效观察

Effect of Compound Ammonium Glycyrrhizic S combined with Leigongtengduogan tablets in the treatment of eosinophil increases caused by chronic eczema

目的观察复方甘草酸单胺S联合雷公藤多甙治疗慢性湿疹引起嗜酸性粒细胞增多的临床疗效。方法采用5分类血细胞分析仪分别对治疗组30例(应用复方甘草酸单胺S联合雷公藤多甙)和对照组30例(应用盐酸西替利嗪胶囊联合富马酸酮替芬)在治疗前后对外周血嗜酸粒细胞计数进行测定,同时记录自觉症状和皮损情况的改善,并对比分析。结果治疗4周后,治疗组嗜酸性粒细胞下降指数的痊愈率及有效率分别为43.33%、96.66%,明显高于对照组的3.33%、30.00%;治疗组TSS下降指数的痊愈率及有效率分别为37.67%、93.34%,明显高于对照组的6.67%、26.67%。差异均有统计学意义(P<0.01)。结论复方甘草酸单胺S联合雷公藤多甙能有效促进嗜酸性粒细胞计数下降,临床症状体征明显改善。

Objective To explore the effect of Compound Ammonium Glycyrrhizic S combined with Leigongtengduogan tablets in the treatment of eosinophil increases caused by chronic eczema.Methods The ECKMAN COULTER LH750 ANALYZER from the United States was used in analyzing the data.Patients were divided into treatment group with 30 patients applied with Compound Ammonium Glycyrrhizic S combined with Leigongtengduogan tablets and the control group with 30 patients applied with the Citirizine Dihydrochloride Capsules combined with Ketotifen Fumarate Tablets.Before and after the treatment,the blood of eosinophil,self-perceived symptoms,and skin damage changes were recorded and compared.Results After 4-week treatment,the recovery and efficiency rate of the eosinophils decline index in the treatment group were 43.33% and 96.66% respectively,which were significantly higher than those in the control group,3.33% and 30.00%.The recovery and efficiency rate of TSS decline index in the treatment group were 37.67% and 93.34%,which were significantly higher than those in the control group,6.67% and 26.67%.It is statistically different（P0.01）.Conclusion Compound Ammonium Glycyrrhizic S combined with Leigongtengduogan tablets can effectively promote eosinophil count drops.Clinical symptoms and physical signs significantly improve.