摘要
目的研究Notch-1抗体在肺类癌(pulmonary carcinoid,PC)表达的临床病理意义。方法采用免疫组化SP法检测40例PC及40例NSCLC癌组织Notch-1抗体的表达,分析其和PC各临床病理参数与预后的关系。结果 Notch-1在PC中的表达率为22.50%(9/40),而在NSCLC中则高达67.50%(27/40)。Notch-1在PC中的表达与临床分期相关,差异有统计学意义(P<0.05)。与NSCLC比较,Notch-1在PC中的表达有显著性差异(P<0.05)。Kaplan-Meier生存分析及Cox比例风险回归分析显示Notch-1阳性患者具有较好的预后(P<0.05)。结论 Notch-1在PC中低表达,与肺类癌临床分期有关。
Objective To appraisal the clinical significance of the expression of Notch-1 protein in pulmonary carcinoid(PC). Methods SP immunohistochemistry was used to detect the expression of Notch-1 antibody in 40 cases of PC and 40 cases of NSCLC tissues. The association between Notch-1 expression with clinicopathological features in PC was analyzed,and prognosis as well. Results The rate of Notch-1 expression was 22.50%(9/40) in PC,and 67.50%(27/40) in NSCLC by contrast.The expression of Notch-1 protein was associated with clinical stage,showing statistically significant (P〈0.05). There was more higher difference (P〈0.05) for Notch-1 expression in the PC than in NSCLC.The survival analysis and Cox proportional hazard regression. The analysis was showed by the methods of Kaplan-Meier and Cox proportional hazard regression that patients with positive NotchM expresion have better prognosis (P〈0.01). Conclusion The lower exression of Notch-1 in PC was associated with the clinical stage of lung carcinoid,but also useful in the differential diagnosis.
出处
《中国现代医生》
2011年第18期8-11,共4页
China Modern Doctor
关键词
肺癌
类癌
NOTCH-1
免疫组化
预后
Lung cancer
Carcinoid
Notch- 1
Immunohistochemistry
Prognosis