肺类癌临床病理特征及Notch-1表达与预后的关系

Clinicopathological Features of Pulmonary Carcinoid and the Relationship of Notch-1 Expression and Prognosis

目的研究Notch-1抗体在肺类癌(pulmonary carcinoid,PC)表达的临床病理意义。方法采用免疫组化SP法检测40例PC及40例NSCLC癌组织Notch-1抗体的表达,分析其和PC各临床病理参数与预后的关系。结果 Notch-1在PC中的表达率为22.50%(9/40),而在NSCLC中则高达67.50%(27/40)。Notch-1在PC中的表达与临床分期相关,差异有统计学意义(P<0.05)。与NSCLC比较,Notch-1在PC中的表达有显著性差异(P<0.05)。Kaplan-Meier生存分析及Cox比例风险回归分析显示Notch-1阳性患者具有较好的预后(P<0.05)。结论 Notch-1在PC中低表达,与肺类癌临床分期有关。

Objective To appraisal the clinical significance of the expression of Notch-1 protein in pulmonary carcinoid（PC）. Methods SP immunohistochemistry was used to detect the expression of Notch-1 antibody in 40 cases of PC and 40 cases of NSCLC tissues. The association between Notch-1 expression with clinicopathological features in PC was analyzed,and prognosis as well. Results The rate of Notch-1 expression was 22.50%（9/40） in PC,and 67.50%（27/40） in NSCLC by contrast.The expression of Notch-1 protein was associated with clinical stage,showing statistically significant （P〈0.05）. There was more higher difference （P〈0.05） for Notch-1 expression in the PC than in NSCLC.The survival analysis and Cox proportional hazard regression. The analysis was showed by the methods of Kaplan-Meier and Cox proportional hazard regression that patients with positive NotchM expresion have better prognosis （P〈0.01）. Conclusion The lower exression of Notch-1 in PC was associated with the clinical stage of lung carcinoid,but also useful in the differential diagnosis.