卵巢癌早期诊断6种肿瘤标记物研究进展

Progress of Six Tumor Markers on Early Diagnosis of Ovarian Cancer

卵巢癌是妇科恶性肿瘤的首要死亡原因,早期诊断并进行干预可以明显改善卵巢癌患者的5年生存率。多年来研究者一直致力于寻找简便高效的早期诊断指标,如CA125/153/724、血浆磷脂溶血酸(LPA)、人附睾分泌蛋白4(HE4)、B7-H4分子、Prostasin基因、间皮素(Mesothelin)等。本文主要对近年来研究较多的肿瘤标记物做一综述。

Ovarian cancer is the primary death cause of gynecologic cancer, early diagnosis and intervention can significantly improve the 5-year ovarian cancer survival rate. Over the years researchers have been dedicated to finding the simple and effective tumor markers on early diagnosis,such as CA125/153/724,plasma lysphosphatidie acid （LPA）,human epididymis protein 4 （HE4）,B7-H4 molecules,prostasin genes, mesothelin, and so on. This paper focuses on more recent studies of tumor markers.