维生素D水平与冠心病及其危险因素的关系

Relative Study of Serum Vitamin D Levels and Coronary Heart Disease and Its Risk Factors

目的探讨血清维生素D(VitD)水平与冠心病及其危险因素的关系。方法将177例患者分别分为冠心病组139例[其中急性冠脉综合征(ACS)亚组88例]和对照组38例;高血压组124例和对照组53例;糖尿病组71例和对照组106例;高胆固醇血症组(高脂组)53例和对照组124例;均测定血清25(OH)D水平,分析VitD水平与冠心病及高血压、糖尿病、高胆固醇血症等冠心病主要危险因素的关系。结果 25(OH)D水平在冠心病组、糖尿病组低于相应对照组,但在ACS亚组、高血压组、高脂组与相应对照组间的差异均无统计学意义。结论 VitD水平与冠心病、糖尿病的发生呈负相关,VitD缺乏可能通过影响血糖等因素而成为冠心病的潜在危险因子。

Objective To investigate the relationship between vitamin D levels and Coronary heart disease and its risk factors preliminarily. Methods 177 patients were respectively divided into Coronary heart disease （CHD） group and the control group （139/38 eases）, Hypertension group and the control group （124/53 cases）,Diabetes group and the, control group （71/106 cases）,Hypercholesterolemia group and the control group（53/124eases）,including 88 cases of acute coronary syndrome as ACS subgroup. Serum 25（OH）D levels were be determined in each group, and effect of VitD in coronary heart disease and its risk factors such as hypertension and diabetes and hypercholesterolemia were all be analyzed. Results According to the resuhs of 25（OH）D levels,the differences between Hypertension group,Hypercholesterolemia .group, ACS subgroups and the corresponding control groups were no statistically significant. The 25（OH）D levels in CHD group and Diabetes group were all significantly below the＇ control groups. Conclusion VitD level negatively correlate with the incidence of CHD and diabetes. Lack of VitD may be the potential risk factor for CHD by affecting factors such as glucose.