血脂检测在肝脏疾病诊断中的临床意义

The Detection of Serum Lipids and Its Value in the Diagnosis of Hepatic Diseases

目的观察各种肝脏疾病血脂水平的变化,探讨其在疾病诊断中的意义。方法采用全自动生化分析仪分别检测本院76例脂肪肝、138例病毒性肝炎、45例肝硬化及39例肝癌患者血脂(甘油三酯TG、总胆固醇TC、高密度脂蛋白胆固醇HDL-C、低密度脂蛋白胆固醇LDL-C及载脂蛋白A1和B)的浓度,与95例健康体检者作比较。结果 与正常对照组相比,病毒性肝炎、肝硬化及肝癌患者TG、TC、HDL-C、LDL-C、apoA1及apoB浓度均有下降,差异具有统计学意义(P<0.05或P<0.01);脂肪肝患者除HDL-C和apoA1有显著性下降外,其余指标水平及阳性率均比正常组升高,差异具有统计学意义(P<0.01)。结论检测血脂水平对诊断各种肝脏疾病有临床价值,可以了解肝实质损伤的程度。

Objective To evaluate the value of the diagnosis of serum lipids in hepatic diseases. Methods The concentration of serum lipids （TG,TC,HDL-C,LDL-C,apoA1 and apoB） in the hepatic diseases patients in our hospital was detected by the automatic biochemical analyzer,including 76 cases of fatty hver, 138 cases of virus hepatitis,45 cases of cirrhosis and 39 cases of hepatic carcinoma. The results were compared with the control group. Results Comparing with the control group, the concentration of serum lipids of virus hepatitis,cirrhosis and hepatic carcinoma were remarkably decreased（P〈0.05 or 0.01）. The HDL-C and apoA1 of Fatty Liver were remarkably increased and the other markers were remarkably decreased （P〈0.01）. Conclusion The detection of serum lipids could be used to diagnose hepatic diseases.