高脂血症患者前列环素、血栓素及D-二聚体的检测与分析

The Assays and Analysis of Prostacyclin,Thromboxane and D-Dimer in Patients with Hyperlipidemia

采用放射免疫法和ＥＬＩＳＡ法测定了６９ 例高脂血症患者６ － 酮－ 前列腺素Ｆ１α（６ － Ｋ－ ＰＧＦ１α） 、血栓素Ｂ２（ＴＸＢ２） 以及Ｄ－ 二聚体（Ｄ－ ｄｉｍｅｒ） 和纤维蛋白（ 原） 降解产物（ＦＤＰ） ，并与２０ 例正常人比较。结果发现高脂血症患者６ － Ｋ－ ＰＧＦ１α低于对照组（ Ｐ＜ ０－０５） ，ＴＸＢ２ 高于对照组（ Ｐ＜０－０１） 。同时，Ｄ－ ｄｉｍｅｒ 和ＦＤＰ也高于对照组（ Ｐ＜ ０－００１） 。高脂血症患者体内处于ＰＧＩ２／ＴＸＡ２ 平衡失调、高凝状态和继发性纤溶亢进，对高脂血症患者定期监测体内凝血和纤溶功能有助于防治动脉粥样硬化。

Plasma samples of 69 hyperlipidemic patients and 20 healthy controls were collected respectively,for the assaying 6-Keto-PGF 1α (6-K-PGF 1α ),thromboxane B 2(TXB 2)(by radioimmunoassay,RIA),D-dimer and fibrinogen degradation products (FDP)(by enzyme-linked immunosorbent assay,ELISA).The results showed that the mean level of plasma 6-K-PGF 1α in hyperlipidemic patients was significantly lower than that in the control subjects(P<0 05).The level of plasma TXB 2 in hyperlipidemic patients was significantly higher than that in the control subjects(P<0 01).The mean plasma D-dimer,FDP in hyperlipidemic group were obviously higher than that in the control group(P<0 001).It is concluded that the hyperlipidemic patients have shown an imbalance of PGI 2/TXA 2 ratio,the hypercoagulable state and secondary hyperfibrinolysis.Regular detection of the coagulation and fibrinolysis in hyperlipidemic patients can usefulness in the prevention and treatment of atherosclerosis(AS).