左室中段室壁缩短率早期评价高血压患者左室舒张功能

Midwall Fractional Shortening Early Evaluate Left Ventricular Diastolic Function in Hypertension

目的 评价左室中段室壁缩短（ｍｉｄｗａｌｌｆｒａｃｔｉｏｎａｌｓｈｏｒｔｅｎｉｎｇ，ＭＦＳ） 率评价高血压患者左室舒张功能的临床价值。方法 对２９２ 例原发性高血压患者进行二维及多普勒超声心动图观察，比较常规测量左室射血分数（ＥＦ），短轴缩短率（ＦＳ）及左室中段室壁缩短率与左室舒张功能的关系。结果 分别以左室肥厚和左室向心性重构分组，发现左室中段室壁缩短率在肥厚组（Ｐ＝０ ．０１１３） 和向心性重构（ Ｐ＝ ０．００００１） 组明显降低，与舒张功能的改变一致，ＥＦ，ＦＳ在分组比较中无显著差异。多元逐步回归分析结果显示：左室中段室壁缩短率ＭＦＳ较ＥＦ，ＦＳ与舒张功能的关系更为密切。结论 超声测量左室中段室壁缩短率对于早期评估高血压患者舒张功能降低具有重要价值。

Aim To determine clinical value of left ventricular midwall fractional shortening (MFS) to evaluaye left ventricular diastolic function in hypertension.Methods Echocardiography and Doppler echocardiography were obtained in 292 essential hypertensive patients,compared the relationship between conventional left ventricular ejection fraction(EF),endocardial fractional shortening(FS),midwall fractional shortening and left ventricular diastolic function.Results Patients with left ventricle hypertrophy and left ventricle concentric remodeling had significant decreased midwall fractional shortening( P =0.0113, P =0.00001)and left ventricular diastolic function;ejection fraction,endocardial fractional shortening had no significant difference in intergroup analysis.Multiple stepwise regression analysis demonstrated midwall fractional shortening had closer relationship with left ventricular diastolic function than left ventricular EF,FS.Conclusions Echocardiographic measuring midwall fractional shortening had important value in early evaluating left ventricular diastolic function in hypertensive patients. [