度冷丁滥用者毛发分段分析及其结果评价

Segmental analysis of hair from meperidine abusers and evaluation of the results

以度冷丁滥用者为研究对象，在度冷丁滥用者毛发中检出度冷丁及代谢物去甲度冷丁、N一羟甲基度冷丁和N-乙酰度冷丁。60例度冷丁滥用者头发中度冷丁和去甲度冷丁的含量分别为103±130ng／mg和117±143ng／mg。度冷丁稳定地存在于头发中，检出时限至少为药后20个月，而去甲度冷丁则随着离头发根距离的增加而降低。头发分段分析揭示度冷丁在毛干中的分布和滥用史、剂量和含量存在相关性。

Using meperidine abusers as subjects for this study, we detected in hair meperidine and its metabolites normeperidine, N - OCH3 - meperidine and N - AC meperidine. The content of meperidine and normeperidine of 60 abusers were 103 ± 13ong/mg and 117 ± 143ng/mg respectively. Meperidine was stably present in hair for at least 20 months. Normependine level decreased from hair root to tip. The seginental analysis of hair revealed that there were correlations between the drug abuse history andthe distribution of drug along the hair shaft, and betweenthe dose of meperidine and its content presented in hair.