苍耳子的化学成分

Chemical Constituents from Fructus Xanthii

苍耳子（Fructus Xanthii）是常用中药,主要用于慢性鼻炎的治疗,有一定的毒性.为明确苍耳子产生生物活性的物质基础,通过溶剂萃取、正、反相反复硅胶柱色谱及MCI柱色谱等方法,对苍耳子80%甲醇提取物进行分离纯化,用质谱、核磁共振谱等方法进行结构鉴定.从正丁醇萃取物中分离鉴定7个化合物：阿魏酸（1）、咖啡酸（2）、绿原酸（3）、4-O-咖啡酰奎宁酸甲酯（4）、6,7-二甲基-1,4-二氢-2,3-喹喔啉二酮（5）、咖啡酸胆碱酯（6）和4′-O-二氢红花菜豆酸钠盐-β-D-葡萄糖苷（7）.其中,化合物4~7为首次从该植物中分离得到.

Cang Er Zhi（Fructus Xanthii）,from the fruit of Xanthium sibiricum Patr.,is a commonly used traditional Chinese medicine for chronic rhinitis with a little toxicity.In order to prove the material of X.sibiricum that produce bioactivities,it is necessary to investigate its chemical constituents.Solvent extraction,repeated column chromatography on silica,C-18 and MCI were used for isolating compounds from the 80% MeOH/H2O extract of X.sibiricum,and MS and NMR spectral evidences were used for structure elucidation.Seven compounds were isolated： Ferulic acid（1）,caffeic acid（2）,chlorogenic acid（3）,4-O-caffeoyl quinic acid methyl ester（4）,N-（1′-D-deoxyxylitolyl）-6,7-dimethyl-1,4-dihydro-2,3-quinoxalinedione（5）,caffeic acid choline ester（6） and dihydrophaseic acid sodium salt 4′-O-β-D-glucopyranoside（7）.Among of them,compounds 4~7 were isolated from X.sibiricum for the first time.Fig1,Ref 10