激光氧液加东莨菪碱辅助治疗儿童难治性癫癎的疗效

Curative Effect of Laser Oxygen Liquid for Scopolamine Adjuvant Therapy on Intractable Epilepsy in Children

目的观察激光氧液加东莨菪碱（LOFS）辅助治疗儿童难治性癫癎的临床效果。方法选择1~14岁难治性癫癎患儿68例,在原有抗癫癎治疗基础上,采用DJF-IA型多功能激光血液治疗仪,以50 g.L-1葡萄糖5~10 mL.kg-1作载体,置于血疗仪中,接受He-Ne激光照射15 min,并充氧,加用东莨菪碱0.01~0.03 mg.kg-1,静脉滴注1次.d-1,每月10 d,连续3个疗程。结果 LOFS辅助治疗前3个月内各类型癫癎发作总频次为每月34 792（659.00±31.24）次;LOFS治疗3个月过程中发作总频次为每月965（14.00±5.36）次,较原基线平均下降89.99%（t=7.36,P〈0.01）,总有效率为95.59%。LOFS治疗前全部患儿脑电图中的性放电率为100%,治疗后脑电图性放电率平均为68.5%,其中7例脑电图完全恢复正常（10.29%）,此7例中6例抽搐次数明显减少,1例抽搐次数未减少。脑电图在治疗前后无明显变化的52例中,发作频次减少≥50%者50例（69.15%）,脑电图的变化与临床症状改善程度不完全一致。结论 LOFS可能成为难治性癫癎的一种新的辅助治疗手段。

Objective To observe the clinical effect of laser oxygen liquid for scopolamine（LOFS）adjuvant therapy on intractable epilepsy in children.Methods Sixty-eight children with intractable epilepsy,aged 1-14 years old,were given LOFS treatment,and meanwhile they were given antiepilepsy drugs as before.LOFS were prepared by the DJF-IA-based multi-function laser blood treatment device,using 50 g·L-1 glucose 5-10 mL·kg-1 as medium in the blood treatment apparatus,accepting 15 min He-Ne laser irradiation and oxygenation,in addition scopolamine 0.01-0.03 mg·kg-1.LOFS was given by intravenous infusion once daily for 10 days every month for 3 months.Results The overall frequency of seizure with various seizure types during 3 months before LOFS treatment was 34 792 times per month,with（659.00± 31.24） mean times per month.It was obviously efficient during 3 months of LOFS treatment,in which the total frequency of various seizures descended to 965 times per month,with（14.00±5.36） mean times per month.The rate of decline was 89.99% compared with that before LOFS treatment（t=7.36,P0.01）,and total effective rate of LOFS was 95.59%.The rate of epileptic EEG discharges in 68 cases before treatment was 100%,then dropped to 68.5% after LOFS was given.EEG became normal and had no epileptic discharges in 7 cases（10.29%）,which indicated the rate of seizure was obviously cut down in 6 cases and no changes in 1 patient.It was contradictory that EEG changes and clinical improvement were not entirely consistent after LOFS treatment,because there were 50 cases（69.15%） whose seizure frequency reduced more than 50%,meanwhile EEG showed no significant change.Conclusion LOFS might be a new effective auxiliary therapy on intractable epilepsy.